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- Ajayi AAL, Mathur R, Halushka PV. Testosterone enhance human platelet thromboxane A2 receptor density and aggregation responses.
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However, testosterone in physiologic doses may even be beneficial in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood circulate in males with established coronary artery disease . Therefore, an interaction of endogenous components of the patient’s danger profile as well as the testosterone dosing may be issues of whether or not antagonistic events occur. Erythrocytosis has been reported as a potential effect of testosterone, which may be useful in sufferers with anemia.
We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat factors utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, likely secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the right coronary artery. Physicians and sufferers should pay consideration to the scientific consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
Patients additionally could also be taking concomitant stimulants, similar to ephedra, which might confound knowledge and the potential for adverse occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used within the treatment of reduced muscle mass and bone density as properly as anemia. The function testosterone may play within the improvement of heart problems has more and more turn out to be the topic of present curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 pure and artificial derivatives of testosterone, could cause a large spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical practice just lately. Other widespread potential antagonistic effects embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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